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This evaluation should include: Visual acuity testing to establish reference measurements for future comparison Intraocular pressure measurement to identify pre-existing glaucoma risk Dilated fundus examination to assess optic nerve health and retinal integrity Optical coherence tomography (OCT) when clinically indicated to document macular and optic nerve structure Visual field testing for patients with diabetes or other vascular risk factors Dose Escalation Protocol Increase Dosage Gradually : Following a gradual dose escalation plan may help reduce the risk of sudden metabolic changes that could affect blood flow to the eyes (ocular perfusion)

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Initially, about 640 articles were identified

doi: 10.1111/1541-4337.12620