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1519,21 The REWIND trial (Researching Cardiovascular Events With a Weekly Incretin in Diabetes) 15 reported statistically significant reductions in major adverse cardiovascular events (relative risk reduction 12%, with a number needed to treat [NNT] of 323, ie, the number of patients who would need to be treated for 1 year to prevent 1 event) and nonfatal stroke (relative risk reduction 24%, NNT 588) in patients who received dulaglutide 1.5 mg once a week compared with placebo