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How This Works IGF-1 LR3 is a synthetic analog of human insulin-like growth factor-1 engineered with an N-terminal extension (13 amino acids) and a glutamic acid substitution at position 3, resulting in significantly reduced binding affinity to IGF binding proteins [1]

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Combination therapy with HDACi and immune checkpoint inhibitors has shown promise in multiple clinical trials, particularly in patients with refractory tumors, where the combination therapy regimen can significantly improve patient survival rates and disease control rates (7880)