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Additionally, mitochondria release apoptosis-inducing factor (AIF) and endonuclease G (Endo G), which mediate caspase-independent apoptosis (Taneja et al., 2001)

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On June 27, 2025, Innovent Biologics, Inc., a leading biopharmaceutical company focused on developing, manufacturing, and commercializing high-quality medicines for oncology, autoimmune, cardiovascular, and metabolic diseases, announced that China's National Medical Products Administration (NMPA) approved Mazdutide, the worlds first dual glucagon (GCG)/glucagon-like peptide-1 (GLP-1) receptor agonist, for chronic weight management in Chinese adults with overweight or obesity