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Several key findings stand out

These outcomes reflect observed biomarker and pathway changes under controlled conditions and are not established therapeutic claims

Placebo, pemetrexed 500 mg/m2, and investigators choice of cisplatin 75 mg/m2 or carboplatin AUC 5 mg/mL/min intravenously on Day 1 of each 21-day cycle for 4 cycles followed by placebo and pemetrexed 500 mg/m2 intravenously every 3 weeks