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1 Introduction Prostate cancer (PCa) ranks among the most incident and lethal malignancies in men globally, representing the second leading cause of solid tumor-related mortality in Europe and the United States ( CRPC transformation mechanisms are complex and multifaceted, involving sustained AR pathway activation ( Lysophosphatidic acid (LPA), a simple-structured glycerophospholipid, functions as a multifunctional bioactive mediator with diverse biological roles ( 2 Fundamentals of lysophosphatidic acid metabolism and signal transduction 2.1 LPA synthesis and degradation LPA is a structurally simple bioactive phospholipid, consisting of a glycerol backbone, a phosphate head, and a single acyl chain ( in vivo condition: unsaturated fatty acids (16:1, 18:1, 18:2 and 20:4) and saturated fatty acids (16:0, 18:0) ( Figure 1 )

As we learn more about obesity, were learning that it is a neuro-hormonal disease