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Additionally, in bleomycin-challenged rodent lungs, setanaxib treatment cut lung hydroxyproline content by 40%, suppressed peroxynitrite formation (assessed via EPR spin trapping), and improved compliance, demonstrating its capacity to interrupt NOX-driven fibrogenesis (Thannickal et al., 2023)
The RMSD of matched atoms between ligands was calculated using LigRMSD 75 with standard settings
Simultaneously, catalytically produced hydrogen peroxide (H 2 O 2 ) activates the protein transient receptor potential melastatin 2 (TRPM2) ion channel, promotes calcium influx, activates macrophages, and induces systemic immune response (Fig
doi: 10.1258/acb.2008.008030
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