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Specifically, in non-diabetic females with a BMI exceeding 35 kg/m 2 , prenatal administration of metformin resulted in reduced maternal weight gain without impacting newborn birth weight (Syngelaki et al., 2016)

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The samples for hepatic metabolomics analysis were part of a larger metabolomics study of the plasma, kidney, heart, and lungdata from which have been reported 6,15

Further experiments were performed downstream of the COX, and we investigated the effect of GS treatment on the expression of mPGES-1, the key terminal synthase responsible for the biosynthesis of the inducible PGE 2