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The reaction in the presence of both enzymes resulted in the formation of a partially soluble blue pigment with the same max as authentic cyanidin ( 8 ) in reaction buffer (Fig

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It is showed that some natural compounds such as flavonoids, phenols, glycosides and coumarins have a protective role in melanocytes and thereby arrest the depigmentation, and, additionally, Nrf2/HO-1, MAPK, JAK/STAT, cAMP/PKA, and Wnt/-catenin signaling pathways were reported to be implicated in these protective effects