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Cohort entry was defined as the date of the first-ever prescription for one of the drugs of interest (GLP-1RAs, SGLT2 inhibitors, metformin or other second- or third-line glucose-lowering drugs) during the study period, and their respective first exposure was defined as the index event

ACSL4 was phosphorylated directly at Thr328 site, which promoted the biosynthesis of polyunsaturated fatty acid (PUFA) lipids (Zhao et al., 2024)

Commonly used for: Arthritis Chronic back pain Joint disorders Usually enteric-coated to reduce stomach irritation