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Data expressed as arbitrary units representing peak areas for a given metabolite relative to peak area of an added norvaline standard for 3HIB and [ 2 H 9 ]l-carnitine (M9 carnitine) internal standard for M4 isobutyrylcarnitine and C3 acylcarnitine

As such, the panel referred to the Centre for Innovation in Regulatory Science (CIRS) data showing the TGAs median approval time of 391 days in 2013fourth out of the six regulators assessed: FDA (USA), Pharmaceuticals and Medical Devices Agency (PMDA, Japan), Health Canada, EMA (EU) and Swissmedic (Switzerland) (median approval time 304, 342, 350, 478 and 511 days, respectively) [12]

The association of vitamin D and vitamin K status with subclinical measures of cardiovascular health and all-cause mortality in older adults: the hoorn study