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Suicidal and self-injurious reports were queried by combining the MedDRA 26.0 preferred terms (PTs) of the standard MedDRA query (SMQ) for suicide/self-injury. The precise terms used were assisted suicide, Columbia suicide severity rating scale abnormal, completed suicide, depression suicidal, intentional overdose, intentional self-injury, poisoning deliberate, self-injurious ideation, suicidal behavior, suicidal ideation, suicide attempt, suicide threat, suspected suicide, suspected suicide attempt. Utilization of globally accepted and clinically validated mesh terms enabled us to effectively address the reports pertaining to the objectives of this study
In a Phase 2 randomised controlled trial published in the New England Journal of Medicine in 2023 (Jastreboff et al., NEJM 2023), adults with obesity (without type 2 diabetes) who received the highest dose of retatrutide (12 mg weekly) achieved a mean body weight reduction of approximately 24% over 48 weeks
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Importantly, an increasing body of evidence from in vitro experiments, animal models, and clinical studies provides support for the efficacy of these natural metabolites
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