10.1016/j.toxlet.2014.04.011 54 LiS.TanH.-Y.WangN.ZhangZ.-J.LaoL.WongC.-W.et al (2015)
Activation of alpha-2 receptors inhibits adenylate cyclase, and lowers intracellular cAMP, which reduces aqueous humour production by the ciliary body
The association between the genes of the -glutamyl cycle and autistic disorder is not well studied, although recently a relatively large study using a pathway approach showed a three-SNP joint interaction effect for glutaredoxin, glutaredoxin 3 and cystathione lyase (OR = 3.78, 95% CI: 2.36, 6.04) as well as marginal associations for cystathione lyase, the gamma-glutamylcysteine synthetase, catalytic subunit and glutaredoxin 3 suggesting that variation in genes involved in counterbalancing oxidative stress may contribute to autism [94]
Almada LL, Barroso K, Sen S, Toruner M, Sigafoos AN, Raja Arul GL, et al