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The 12 mg dose subgroup showed the greatest reduction with an MD of 1.54 (95% CI: 2.47 to 1.55, P = 0.14), with significant heterogeneity ( P = 0.00001, I 2 = 98%) ( Table 3 , Supplemental Figure S7)

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[1] These effects result from the medication's action on gastric motility and may be exacerbated by the appetite-suppressing effects of phentermine, potentially leading to inadequate nutritional intake, dehydration, or electrolyte imbalances