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Some are similar in action of the vasoactive intestinal peptide (VIP), which relaxes smooth muscle and regulates water and electrolyte secretion between the small and large intestines

Several medicinal plant species, including Argemone mexicana, Coscinium fenestratum, and Tinospora cordifolia, contain berberine in their bark, leaves, twigs, roots, and stems (Neag et al., 2018)

10.1208/aapsj080362 29 TianY.ShiH.ZhangD.WangC.ZhaoF.LiL.et al (2023)