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The intramolecular thiolate group is released from its disulphide-bound form by reaction with a thiolate group from cysteine or glutathione and the intramolecular nucleophile triggers the reaction cascade leading to the formation of three lanthionine-bound molecular units within the amino acid sequence of MT and of three units of cadmium sulphide

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The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019)