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The two pathways converge on GH release but through different intracellular cascades, which is why combining a GHS-R1a agonist (like ipamorelin) with a GHRH analog (like CJC-1295) produces a synergistic rather than merely additive GH response

There are ongoing studies including a large phase 3 trial underway to determine if semaglutide will meet any of these clinical endpoints for FDA approval

Clinical Implications Patients taking GLP-1-RA may be at an increased risk for aspiration of gastric contents because of delayed gastric emptying, even if proper preoperative fasting guidelines have been followed

Results vary, and no treatment is right for everyone