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Animal welfare: In in vivo studies, protocols must be approved by an Institutional Animal Care and Use Committee (IACUC) and designed to minimize distress

Two Different Mechanisms, Not Overlapping Ones A common framing is that combining these drugs is risky because their mechanisms overlap

Tesofensine is in development

Merck can choose to fight you on your individual claim but, if you establish those two factors you will likely either win or extract a fair settlement