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Discussion 1) The results of this study completed by McCoy et al systematically evaluated the metabolic stability, BBB permeability, procognitive activity, and synaptogenic potential of Dihexa and other Nle-AngIV analogs, ultimately aiming to identify a therapeutic agent for dementia

Although the data was collected for GHK without copper, we cannot exclude the possibility that the actual gene regulator was the GHK copper complex formed in the culture media, since, as it was mentioned above, GHK can easily obtain copper from other biological molecules such as albumin