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Validating urine-based biomarkers (e.g., cyst-derived exosomal ferroptosis regulators and lipid peroxide metabolites) or circulating signatures that correlate with ADPKD disease stage, cyst growth rate, or response to ferroptosis modulators is urgently needed to guide clinical trial design and patient stratification

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As shown by Sun et al., treatment with GLP-1RAs reshaped gut microbial composition by increasing the abundance of beneficial genera such as Lactobacillus and Bifidobacterium

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