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Given that such data are not entirely homogenous with RCTs in terms of design and control conditions, they are best utilized as exploratory indicators of potential effect ceilings and accessibility to calibrate clinical expectations, rather than as direct points of comparison for placebo-controlled RCTs

Nauck and Meier, 2018

Weight regain and insufficient weight loss after bariatric surgery: definitions, prevalence, mechanisms, predictors, prevention and management strategies, and knowledge gaps-a scoping review

By adding in GHK-Cu, wrinkles are further reduced as the skin begins to produce more collagen and elastin, the elements of the skin that decrease as we age and cause aging skin damage