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proceedings of the national academy of sciences

Available at: Accessed 7/14/2014

Treatment with LY2409021, a glucagon receptor antagonist, increases liver fat in patients with type 2 diabetes

By contrast, the genotype with the N238K mutation evolved by the D3 protease only modestly benefited the WT background, increasing circuit activation when grafted into the WT protease only 1.5-fold, whereas the same genotype in the D3 background enhanced luciferase activation 5.6-fold (Fig