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Etiology Gamma-glutamylcysteine synthetase catalyzes the first and rate-limiting step in the synthesis of glutathione (GSH) (Figure 1) [9]

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OTC products cannot be tailored to these genetic differences, whereas prescription options allow providers to adjust dosing and formulation based on individual response patterns

In addition, AST dietary intervention upregulated GLS synthesis gene mRNA expression (soat, st3gal5, st3fal2, st8sia1, b3galt4, and siae) while downregulating GLS catabolism gene hexa expression (Wang Z