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The protective effect may be achieved either by directly neutralizing the ROS/RNS/other free radical species by the transfer of hydrogen atom and sequential proton loss electron transfer, maintaining the cellular redox balance, thereby protecting the cellular milieu from oxidative impairment, or upregulating the expression of cellular defensive genes or regulating various antioxidant signaling pathways

Key advantages include: For agar-based nanoparticles, TfR ligands represent a highly practical starting point due to their balance of efficiency and ease of chemical conjugation

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