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A 2017 study found that the drug improved insulin sensitivity in the heart by 75%, augmented insulin sensitivity in skeletal muscle tissue by 71% and increased both cardiac ejection fraction and coronary blood flow by more than 10%

(The mechanism is still being clarified.) Risks, limits, and who should not use them GLP-1s can cause GI side effects (nausea, vomiting), are contraindicated in certain endocrine conditions, and can interact with other medications

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After Wegovy and Ozempic stayed on the drug shortage list for nearly three years, the Food and Drug Administration (FDA) announced on February 21, 2025, that semaglutide is no longer in shortage