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As a triple-receptor agonist, Retatrutide must maintain binding affinity for GLP-1, GIP, and glucagon receptors simultaneously, requiring sophisticated molecular design to achieve balanced activation across all three receptor systems

The attached antibodies were detected using horseradish-peroxidase-conjugated rabbit anti-hamster IgG antibody (Thermo Fisher Scientific

doi:10.1074/jbc.R113.458810

Conen, D, Ke Wang, M, Popova, E, Chan, MT, Landoni, G, Cata, JP, Reimer, C, McLean, SR, Srinathan, S, Reyes, JT, Grande, AM, Tallada, AG, Sessler, DI, Fleischmann, E, Kabon, B, Voltolini, L, Cruz, P, Maziak, D, Gutirrez-Soriano, L, McIntyre, WF, Tandon, V, Martnez-Tllez, E, Guerra-Londono, JJ, DuMerton, D, Wong, RH, McGuire, AL, Kidane, B, Roux, DP, Shargall, Y, Wells, JR, Ofori, SN, Vincent, J, Xu, L, Li, Z, Eikelboom, JW, Jolly, SS, Healey, JS, Devereaux, PJ, Wang, MK, Wells, JR, Healey, JS, McIntyre, WF, Sessler, DI, Rajaram, R, Vaporciyan, AA, Mehran, RJ, Sepesi, B, Walsh, GL, Rice, DC, Swisher, SG