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Recent studies show that sodium-glucose cotransporter 2 (SGLT2) inhibitors can not only protect the kidneys by reducing blood sugar, improving hemodynamics and reducing proteinuria ( 2 Ferroptosis in DKD: pathogenesis and evidence 2.1 Molecular and biochemical features First proposed by Stockwell and colleagues in 2012,ferroptosis is a regulated form of cell death driven by iron dependency and lipid peroxidation ( At the biochemical level, ferroptosis is driven by three core processes