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Conflict of Interest TK has received honoraria for lectures from AstraZeneca, Boehringer Ingelheim, Pharmaserve Lilly, and Novo Nordisk, for advisory boards from Novo Nordisk, and has participated in sponsored studies by Eli-Lilly and Novo Nordisk

In particular, the development of new neurological symptoms (e.g., hypoesthesia or dysesthesia), pain, and/or enlargement of an existing plexiform neurofibroma should raise suspicion for malignant transformation into an MPNST [26]

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The clinical evidence for Rhodiola rosea is supported by multiple randomized, double-blind, placebo-controlled trials, including a phase III study evaluating the standardized extract SHR-5, which demonstrated statistically significant improvements in depressive symptoms with a favorable tolerability profile