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Bremer E, Calteau A, Danchin A, Harwood C, Helmann JD, Mdigue C, Palsson BO, Sekowska A, Vallenet D, Zuniga A, et al

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This latter observation suggests that native pairing, while stabilizing the antibody structure and functional paratopes, does not necessarily reduce its propensity to partially unfold and expose hydrophobic residues that are traditionally buried in its native state