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At 8 weeks of age, Shannon diversity index (within sample) was comparable ( p = 0.200), but decreased in O-ZSF1 at 13 weeks, when HFpEF had manifested, and remained lower until the rats were sacrificed at 20 weeks ( p = 0.003 and p = 0.074) (Fig

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Optimization of Targeted Strategies Surface modification: By adjusting the surface properties of the drug carrier, such as increasing the surface density of the targeting ligand or changing the charge properties on the carrier surface, the targeting ability of BPC 157 can be improved