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However, our earlier observations in the same species (unpublished data) did not reveal any significant differences in renal morphology or urinary protein excretion between SHR and WKY rats aged 416 weeks, except after 48 weeks of age when significant decreases in glomerular filtration rate and glomerular necrosis was evident in SHR

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Native IGF-1 and, by extension, the mature core of any IGF-1 variant are avidly captured by IGFBPs, which limits free concentration and shortens the effective signaling window

[4] Le glutathion intervient dans cette transformation : il se lie ces substances grce une famille d'enzymes appeles glutathion-S-transfrases