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Three RCTs [3234] involving 204 patients provided moderate certainty evidence (Table 2) that L-carnitine supplementation significantly changes in the HDL cholesterol levels (MD: 1.14, 95%CI: 0.21 to 2.07) and low certainty evidence (Table 2) that L-carnitine supplementation may induce or no difference on changes in the LDL cholesterol levels (MD: 6.80, 95%CI: 23.27 to 9.68)

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Como punto de partida, la Alianza Internacional de Asociaciones de Suplementos Alimentarios (IADSA, en sus siglas inglesas) present en 2007 un informe en el que cita los estudios cientficos que se han realizado para determinar las dosis de seguridad de nutrientes como glucosalina, omega-3, creatina, coenzima Q-10, condroitina, carnitina, lutena y licopeno