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As the insulin receptor is expressed in all cell types and insulin signaling mediates diverse cellular functions, the detailed insulin function of each tissue has been extensively studied using tissue-specific Insr knockout mice 3,5 , in which Insr expression is almost completely disrupted in a specific cell type

Since semaglutide further slows gastric emptying as part of its mechanism of action, patients with pre-existing gastroparesis may experience worsening of symptoms including nausea, vomiting, bloating, and abdominal discomfort

[DOI] [PubMed] [Google Scholar] 50.Watanabe T., Hoshi K., Zhang C., Ishida Y., Sakata I

Sohrabpour, S