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Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth
Research consistently shows poor absorption in pill or capsule form, as glutathione is a protein that is dismantled into its component amino acids during the digestive process, preventing the intact antioxidant from reaching circulation
Targeting ligands may include monoclonal antibodies (e.g., trastuzumab targeting HER2), peptides (e.g., RGD motifs for integrins), aptamers, or small molecules such as folic acid [113,114,115,116]
These testimonials focus on digestive applications where oral delivery makes intuitive sense
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