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In the context of constitutive HIF-2 stabilization 75 or a defective mitochondrial electron transport chain 76 , glutamine-derived -KG is reductively carboxylated through the consumption of NADPH by IDH2 to generate citrate

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Chakraborty N, Mitra R, Dasgupta D, Ganguly R, Acharya K, Minkina T, Popova V, Churyukina E, Keswani C