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Coley's toxins, tumor necrosis factor and cancer research: a historical perspective

Subcision techniques (Cellfina, Avli) mechanically release fibrous bands, showing improvement lasting 1-3 years in FDA-reviewed studies

Quasi-closed system A system is closed if there is no interaction with the external environment

In some embodiments, the otoprotectant is a compound of Formula (XI) having the structure of Formula (XIa): In some embodiments, the otoprotectant is any one of the following compounds: or a pharmaceutically acceptable salt, pharmaceutically acceptable solvate or hydrate, pharmaceutically acceptable salt hydrate, or pharmaceutically acceptable prodrug thereof