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Similarly, the role of Fra2/BolA2 in human cells is largely unknown, although the mitochondrially targeted BolA3 is involved in FeS cluster acquisition and/or maintenance for some mitochondrial FeS enzymes, especially lipoate synthase ( PROTEINS INVOLVED IN CYTOSOLIC IRON DISTRIBUTION: PCBPs The term metallochaperone has been used to describe proteins that directly deliver metals to target enzymes or transporters through metal-mediated proteinprotein interactions ( The role of PCBP1 in the mineralization of ferritin was initially identified through functional screening of a human liver cDNA library in a eukaryotic model lacking endogenous ferritin expression, i.e., Saccharomyces cerevisiae ( In vitro experiments with purified PCBP1 and ferritin supported the direct involvement of PCBP1 in the mineralization of ferritin by a dose-dependent enhancement in the incorporation of iron into apoferritin by the chaperone protein

The role of GLP-1 in mediating the function of GCs and the oocyte development in PCOS was investigated by Sun Z et al