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Companies will have to carefully plan elements of trial design, including who to treat, when to treat and end points to use to increase the likelihood of positive findings

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Diabetes Care 33:730732 Migoya EM, Bergeron R, Miller JL et al (2010) Dipeptidyl peptidase-4 inhibitors administered in combination with metformin result in an additive increase in the plasma concentration of active GLP-1

The Sikiric group has published extensively on gastric ulcer, TNBS-induced colitis, and hepatic ischemia-reperfusion models (Sikiric et al