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While many people take high doses for long periods, it is often best to use a 1500 mg dose for a specific period (such as 36 months) to reach a goal, and then transition to a lower maintenance dose

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286 Besides, -catenin responsive transcription (CRT) is another crucial therapeutic target in combating various cancers and CRT-inhibitory drugs (iCRT3, iCRT5, iCRT14) are specifically cytotoxic to human colon cancer cells and enhance the infiltration of T and NK cells in syngeneic mouse models of CRC by blocking -catenin/TCF interaction