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If the primary outcome showed superiority, secondary outcomes were tested in a pre-specified order to control the type I errors Total eGFR slope (the annual rate of change in eGFR from randomization to the end of the trial) Major cardiovascular events (a composite of nonfatal MI, nonfatal stroke, or death from CV causes) Death from any cause The other supportive secondary outcomes are shown in the figure below

Emotional Stress and Hormonal Changes Starting a new medication, adjusting to lifestyle changes, or coping with the psychological impact of chronic illness can all represent stressors

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