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In cancer cells, cellular GSH levels are influenced not only by upregulated xCT (SLC7A11) but also by altered glutamate transporters, particularly EAAT3

This occurs both inside and outside the blood vessels of the gastrointestinal tract, presenting a wide range of potential uses

Zhangs study demonstrated that the synthesis of GSH is intricately linked to serine metabolism, with its metabolic byproducts lactate and 2-hydroxyglutarate (2-HG) suppressing the cytotoxic function of T cells

Infections may also contribute to HT via molecular mimicry, in which structural or amino acid sequence similarities between microbial and human antigens induce cross-reactive immune responses, accelerating the development of autoimmunity (da Silva et al