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It also degrades GIP (glucose-dependent insulinotropic polypeptide), another incretin hormone that coordinates insulin secretion with nutrient absorption

This marks the first time a regulatory authority has formally acknowledged the link, following multiple studies suggesting an increased risk of NAION among type-2 diabetes patients taking semaglutide

The agencies not only ensured safety but also facilitated the expansion of therapeutic indications for GLP-1R agonists, including obesity and cardiovascular risk reduction

Alcohol should be limited or avoided entirely , as it can irritate the gastric lining and may increase the risk of hypoglycaemia, particularly in patients also taking insulin or sulfonylureas for diabetes