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GPX4 released from ferroptotic cancer cells functions as a DAMP that suppresses antitumor immunity by engaging the zona pellucida glycoprotein 3 (ZP3) receptor on dendritic cells 101

In one trial, 16 people placed on experimental bed rest for 3 weeks (in order to increase urinary calcium excretion by causing bone breakdown) and treated with 20 mg per day of the bisphosphonate alendronate had lower urine calcium concentrations, and lower calcium oxalate and calcium phosphate saturations, compared with placebo (Ruml 1995)

Kim KH, Seol HJ, Kim EH, Rheey J, Jin HJ, Lee Y, et al