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When NNMT activity is high: NAD levels drop, impairing mitochondrial energy production

In addition to dopamine, norepinephrine, and epinephrine, the VMAT transporters, in particular VMAT2, are responsible for vesicular import of serotonin (5-HT), histamine, and several trace amines such as the tyramines [para-tyramine ( p -tyramine), meta-tyramine ( m -tyramine), 3-methoxytyramine, and N-methyltyramine], -phenylethylamine (-PEA), and thyronamine (3-iodothyronamine)

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