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That said, theres minimal risk to trying PQQ supplements

The peptide stimulates the activity of enzymes involved in ceramide biosynthesis, including serine palmitoyltransferase and ceramide synthase

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Egypt Pharm J 20(2):134144 Matsuu-Matsuyama M, Shichijo K, Matsuda K, Fujimoto N, Kondo H, Miura S, Kurashige T, Nagayama Y, Nakashima M (2021) Age-dependent effects on radiation-induced carcinogenesis in the rat thyroid