Based on the above results and our previous findings that inhibiting the cGAS-STING signaling pathway could suppress ferroptosis in skeletal stem cells derived from costal cartilage tissue [34], we hypothesized that GLP-1RAs might inhibit ferroptosis of chondrocytes by suppressing the activation of the cGAS-STING signaling pathway, and promote the synthesis of glycosaminoglycans and chondroitin sulfate, thereby alleviating the development of RA
Blood pressure (BP), anthropometric characteristics, markers of liver function, metabolic indices (plasma glucose, lipid profiles, uric acid, free fatty acid and insulin) and hypersensitivity C-reactive protein were measured
Compounded semaglutide is not licensed by the MHRA for use in the UK and has been the subject of regulatory safety warnings
Strategies to mitigate Dox-induced cardiac damage include dose reduction, slow infusion protocols, and specialized formulations such as liposomal preparations 5,6,8