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Interestingly, our lab recently identified the widely clinically used anti-depressant sertraline as a potent SHMT inhibitor that selectively inhibits proliferation of serine synthesis addicted cancer cells (8)

Many patients remain at lower doses for longer periods if they are experiencing adequate appetite control and weight-loss progress

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The authors also examined the synergistic effect of naringenin with sertraline in mice with depression and discovered that the combination of these two substances alleviated depressive-like behavior through the regulation of the 5-HT level and protection of the mitochondrial complexes pathway, as well as by reducing oxidative stress in the hippocampus