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The most robust evidence to date comes from a phase 2 randomised controlled trial (Jastreboff et al., New England Journal of Medicine , 2023), in which retatrutide was evaluated over 48 weeks in adults with obesity but without type 2 diabetes

Lactobacillus paracasei supplementation prevents early life stress-induced anxiety and depressive-like behavior in maternal separation model-possible involvement of microbiota-gut-brain axis in differential regulation of MicroRNA124a/132 and glutamate receptors

Cellular stress signaling and the unfolded protein response in retinal degeneration: mechanisms and therapeutic implications

Moreover, the metabolite markers associated with responders and non-responders to metformin are not clearly established as either a cause or an effect of genetic alterations on the pharmacokinetics of metformin (Florez, 2017)