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Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15

Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

Patients are often advised to maintain a balanced diet rich in fiber to help alleviate constipation and to stay mindful of their food choices, as certain foods may trigger digestive upset

Known history or presence of severe acute or chronic liver disease (compensated or decompensated), known cholelithiasis or cholecystitis or bile duct disease, acute or chronic pancreatitis (or medication associated with severe pancreatitis, such as valproate) or severe gastrointestinal dysmotility syndrome, including functional disorders such as severe irritable bowel syndrome