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Because testicular biopsy can damage the testes, its use is limited to highly specific cases and is often performed in conjunction with testicular sperm extraction for cryopreservation (freezing) and possible use in assisted reproductive strategies

However, while GLP-1 RAs did not exhibit an increased risk of acute pancreatitis, DPP-4 inhibitors demonstrated a notable risk elevation (rate ratio, 1.75) [53]

Extended-duration effects of GLP-1 RAs and multi-agonists on liver-associated outcomes involving cirrhosis development, HCC incidence, and death from hepatic causes are being elucidated through ongoing observational studies and long-term trial extensions [65-70]

In fact, one clinical trial demonstrated that tirzepatide led to participants achieving an average weight loss of 20 pounds over 52 weeks